A SpaceX Falcon 9 rocket launched Dragon’s 33rd Commercial Resupply Services (CRS-33) mission to the International Space Station from Space Launch Complex 40 (SLC-40) at Cape Canaveral Space Force Station at 2:45 a.m. on 24 August 2025. Following stage separation, Falcon 9's first stage landed on the A Shortfall of Gravitas droneship stationed in the Atlantic Ocean.

CRS-33 is the third flight for the Dragon spacecraft supporting this mission, which previously flew CRS-26 and CRS-29, bringing scientific investigations, supplies, and equipment to and from the International Space Station.

This will be the seventh flight of the first stage booster supporting this mission, which previously launched O3b mPOWER-E, Crew-10, Bandwagon-3, O3b mPOWER-D, and two Starlink missions.